By Dr. Mukherjee, Consultant Nephrologist
Kidneys are silent workers of our body — filtering waste, balancing fluids, regulating blood pressure, and supporting red blood cell production. But when they begin to fail, the early signs are often subtle, making kidney disease a “silent threat.”
As a nephrologist, I often meet patients who come in at a later stage of kidney dysfunction, unaware that their body had been giving them warnings all along. In this article, I’ll walk you through the 10 early signs of kidney damage that everyone should know.
When kidneys don’t filter toxins effectively, waste builds up in the blood. This leads to a drop in red blood cell production, causing fatigue, weakness, and lack of energy — often dismissed as stress or age-related tiredness.
One of the first visible signs of kidney dysfunction is swelling in the ankles, feet, hands, or around the eyes. This happens because the kidneys can’t eliminate excess fluid from the body effectively.
Pay attention to your urine habits:
Frequent urination, especially at night
Foamy or bubbly urine
Blood in the urine
Decreased urine output
These are early indicators that your kidneys may not be filtering properly.
Fluid buildup in the lungs — due to poor kidney function — can lead to difficulty breathing or a feeling of tightness in the chest, especially when lying down.
Healthy kidneys maintain the right balance of minerals in your blood. When this balance is disrupted, you may experience persistent itching or dryness, often on your back, arms, or legs.
Toxin buildup in the bloodstream can affect your digestive system, leading to nausea, vomiting, and a metallic taste in the mouth.
If you’re suddenly disinterested in food, especially protein-rich meals, it might be due to an accumulation of urea and other waste products in your body — an early red flag.
Kidney disease disrupts the body’s electrolyte balance. Low levels of calcium or uncontrolled phosphorus can cause frequent leg or back cramps, especially at night.
Your kidneys regulate blood pressure through fluid balance and hormone control. When damaged, they can contribute to uncontrolled or resistant hypertension, creating a vicious cycle of worsening kidney health.
Reduced kidney function can lead to anemia, which affects oxygen delivery to the brain. This can cause dizziness, memory problems, or trouble focusing — symptoms often misattributed to aging or stress.
If you notice any of these signs, don’t ignore them. Early diagnosis is key in managing and even reversing some forms of kidney disease.
Serum Creatinine
eGFR (Estimated Glomerular Filtration Rate)
Urine Albumin-to-Creatinine Ratio
Ultrasound KUB (Kidney, Ureter, Bladder)
As a nephrologist, my goal is to help patients preserve kidney function and maintain quality of life — through early detection, lifestyle changes, and evidence-based treatment.
Stay informed. Stay proactive. Your kidneys will thank you.
– Dr. Mukherjee
Consultant Nephrologist
Prof (Dr) D Mukherjee is an alumnus of the prestigious Armed Forces Medical College, Pune where he did his MBBS & MD (Medicine). Subsequently he went on to do his DM (Nephrology) from PGIMER Chandigarh, which is the foremost training institution for nephrology in India.