High Flux Dialysis

High Flux Dialysis

High-flux hemodialysis confers a definite survival advantage in high-risk patients compared with low-flux hemodialysi.

Hemodialysis can be done by low flux or high flux membrane. High-flux dialysis is defined as a β2-microglobulin clearance of over 20 ml/min . High flux membranes compared to low flux have larger pores and allow diffusion of greater amounts of uremic toxins and middle molecules such as β2 microglobulin and therefore they may decrease the risk of dialysis-related amyloidosis . In addition, these membranes have other advantages like increasing patients’ survival , reduced admission and morbidity, less activation of coagulation pathway and complement system, less leukocytosis and activation of inflammatory system and cytokines secretion, removing more endotoxins, better lipid profile , reduced infection risk, aluminum toxicity and better preserved renal function .